The determination of this parameter allows for screening of drug candidates and an understanding of thier solution behaviour under This Standard Operating Procedure (SOP) details the individual steps involved in calibration with USP disintegrating tablets (Prednisone) and non-disintegrating tablets (salicylic acid).
Therefore we develop a new hybrid particle simulation algorithm to study the dissolution of solid objects in a laminar flow field, as encountered in porous media flow situations. Experimentally, it is hard to investigate this process at the pore scale. This may result in dissolution of the mineral grains in the porous medium. In CO2 sequestration operations, CO2 injected into a brine aquifer dissolves in the liquid to create an acidic solution.
We discuss the evolution of the shape and dissolution rate. Second, we calculate the dissolution of a cylinder in channel flow in direct comparison with corresponding dissolution experiments. Then we consider the dissolution of a solid sphere in a laminar flow field and observe a significant change in the sphericity with time due to the coupled dissolution - flow process. We compare with the analytical solution for this problem and find good agreement. To validate our simulation, we first calculate the dissolution of a solid sphere as a function of time under quiescent conditions. Second, using a stochastic particle approach, we solve the advection-diffusion equation for a single reactive species and dissolve solid voxels according to our reaction model.
This is of great importance for CO2 storage and Enhanced Oil Recovery applications. It turns out that the hybrid simulation model is a suitable tool to study reactive flow processes at the pore scale. This work builds on our recent research on calculation of multi-phase flow , and hydrodynamic dispersion and molecular propagator distributions for solute transport in homogeneous and heterogeneous porous media using LB simulations.
65, 882-890 (2013) Yang, J. 59, 2305-2314 (2010) Yang, J.
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